Ontology highlight
ABSTRACT:
SUBMITTER: Khodade VS
PROVIDER: S-EPMC8208316 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Khodade Vinayak S VS Aggarwal Sahil C SC Pharoah Blaze M BM Paolocci Nazareno N Toscano John P JP
Chemical science 20210514 23
The recent discovery of the prevalence of hydropersulfides (RSSH) species in biological systems suggests their potential roles in cell regulatory processes. However, the reactive and transient nature of RSSH makes their study difficult, and dependent on the use of donor molecules. Herein, we report alkylsulfenyl thiocarbonates as a new class of RSSH precursors that efficiently release RSSH under physiologically relevant conditions. RSSH release kinetics from these precursors are tunable through ...[more]