Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease.

ABSTRACT:

Background

Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using ^99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD).

Methods

Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying sizes), filled with ^99mTc-pertechnetate, were performed on a SPECT/CT (Discovery 670 Pro, GE Healthcare). Subsequently, volumes of interest of the defects were manually drawn on CT to assess the recovery coefficient (RC). Bull's eye plots were composed to evaluate the

SUBMITTER: van de Burgt A 

PROVIDER: S-EPMC8208344 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature