Positron Emission Tomography Imaging of Regional Versus Global Myocardial Sympathetic Activity to Improve Risk Stratification in Patients With Ischemic Cardiomyopathy.

ABSTRACT:

Background

Current risk assessment approaches fail to identify the majority of patients at risk of sudden cardiac arrest (SCA). Noninvasive imaging of the cardiac sympathetic nervous system using single-photon emission computed tomography and positron emission tomography offers the potential for refining SCA risk assessment. While various [¹¹C]meta-hydroxyephedrine quantification parameters have been proposed, it is currently unknown whether regional denervation or global innervation yields greater SCA risk discrimination. The aim of the study was to determine whether the global innervation parameters yield any independent and additive prognostic value over the regional denervation alone.

Methods

In a post hoc competing-risks analysis of the PAREPET trial (Predict

SUBMITTER: Zelt JGE 

PROVIDER: S-EPMC8208501 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature