Dataset Information

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.

ABSTRACT:

Objective

This study aimed to look for a possible relationship between thyrotropin (TSH) values from neonatal bloodspot screening testing and newborn lower auditory pathway myelinization evaluated using the brainstem evoked response audiometry (ABR) test.

Methods

Sixty-two healthy full-term newborns without perinatal problems were enrolled in the study. TSH results were collected from neonatal bloodspot screening data and were below the test cut-off level (15μUI/mL). The TSH test was performed between three and seven days, and the ABR test was performed in the first 28 days of life. The newborns were divided into two groups: Group 1 (n = 35), TSH between 0 and 5μUI/mL, and group 2 (n = 27), TSH between 5 and 15μUI/mL. Data are presented as mean ± SD, median, or percentage, depending on the variable.

Results

Wave latency and interpeak interval values for Groups 1 and 2 were as follows: Wave I: 1.8 ± 0.1 and 1.7 ± 0.1; Wave III: 4.4 ± 0.1 and 4.4 ± 0.1; Wave V: 6.9 ± 0.1 and 6.9 ± 0.1; interval I-III: 2.6 ± 0.1 and 2.6 ± 0.1; interval I-V: 5.1 ± 0.1 and 5.1 ± 0.1; interval III-V: 2.4 ± 0.1 and 2.4 ± 0.1. There were no significant differences in ABR parameters between groups 1 and 2 (p > 0.05). Multiple regression analysis showed a slight significant negative correlation between TSH and wave I values (standardized β = -0.267; p = 0.036), without observing any relationship with the other ABR waves recorded.

Conclusions

This study investigated the relationship of TSH and auditory myelinization evaluated by ABR. It did not show a significant change in lower auditory pathway myelinization according to TSH levels in newborns with TSH screening levels lower than 15 μUI/mL.

SUBMITTER: Pallone LV

PROVIDER: S-EPMC8208557 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.

Pallone Leticia Valerio LV Navarra Laura Carvalho LC Gonçalves Gleice Aline GA de Jesus Felipe Alves FA Melo Debora Gusmão DG Ferreira Rodrigo Alves RA Germano Carla Maria Ramos CMR

PloS one 20210616 6

<h4>Objective</h4>This study aimed to look for a possible relationship between thyrotropin (TSH) values from neonatal bloodspot screening testing and newborn lower auditory pathway myelinization evaluated using the brainstem evoked response audiometry (ABR) test.<h4>Methods</h4>Sixty-two healthy full-term newborns without perinatal problems were enrolled in the study. TSH results were collected from neonatal bloodspot screening data and were below the test cut-off level (15μUI/mL). The TSH test ...[more]

PMID: 34133461

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Dataset Information

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.

Objective

Methods

Results

Conclusions

Publications

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.

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