Primary Ovarian Insufficiency in Women With Addison's Disease.

ABSTRACT:

Context

Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison's disease (AAD) than in the general population, but their clinical characteristics are insufficiently studied.

Objective

To assess the prevalence of POI in a large cohort of women with AAD and describe clinical, immunological, and genetic characteristics.

Methods

An observational population-based cohort study of the Norwegian National Addison Registry. The Norwegian Prescription Database was used to assess prescription of menopausal hormone replacement therapy (HRT). A total of 461 women with AAD were studied. The primary outcome measure was prevalence of POI. Secondary outcomes were clinical characteristics, autoanti

SUBMITTER: Vogt EC 

PROVIDER: S-EPMC8208662 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature