Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT:

Context

Atrial fibrillation (AF), cardiac arrhythmias, and related risk factors are common in patients with Cushing's syndrome, or clinical chronic hypercortisolism. While hypercortisolism may be associated with AF, this association has not yet been ascertained causally.

Objective

To determine whether plasma cortisol is causally associated with AF using a 2-sample Mendelian randomization (MR) design.

Methods

Three genetic variants in the SERPINA1/SERPINA6 locus and functionally associated with plasma cortisol were identified in the CORtisol NETwork consortium (12 597 participants). Summary-level genome-wide association study (GWAS) data for the associations between the cortisol-associated variants and AF were obtained from a GWAS meta-analysis of 6 studies (60 620 AF

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC8208666 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature