Whole-genome comparative analysis of Malaysian Burkholderia pseudomallei clinical isolates.

ABSTRACT: Burkholderia pseudomallei, a soil-dwelling Gram-negative bacterium, is the causative agent of the endemic tropical disease melioidosis. Clinical manifestations of B. pseudomallei infection range from acute or chronic localized infection in a single organ to fulminant septicaemia in multiple organs. The diverse clinical manifestations are attributed to various factors, including the genome plasticity across B. pseudomallei strains. We previously characterized B. pseudomallei strains isolated in Malaysia and noted different levels of virulence in model hosts. We hypothesized that the difference in virulence might be a result of variance at the genome level. In this study, we sequenced and assembled four Malaysian clinical B. pseudomallei isolates, UKMR15, U

SUBMITTER: Ghazali AK 

PROVIDER: S-EPMC8208702 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature