NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias.

ABSTRACT:

Aims

Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with enhanced inflammatory response. However, whether inflammatory signaling is causally linked to AF pathogenesis in obesity remains elusive. We recently demonstrated that the constitutive activation of the 'NACHT, LRR, and PYD Domains-containing Protein 3' (NLRP3) inflammasome promotes AF susceptibility. In this study, we hypothesized that the NLRP3 inflammasome is a key driver of obesity-induced AF.

Methods and results

Western blotting was performed to determine the level of NLRP3 inflammasome activation in atrial tissues of obese patients, sheep, and diet-induced obese (DIO) mice. The increased body weight in patients, sheep, and mice was associated with enhanced NLRP3-inflamma

SUBMITTER: Scott L 

PROVIDER: S-EPMC8208743 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature