Quantification of spatial tumor heterogeneity in immunohistochemistry staining images.

ABSTRACT:

Motivation

Quantitative immunofluorescence is often used for immunohistochemistry quantification of proteins that serve as cancer biomarkers. Advanced image analysis systems for pathology allow capturing expression levels in each individual cell or subcellular compartment. However, only the mean signal intensity within the cancer tissue region of interest is usually considered as biomarker completely ignoring the issue of tumor heterogeneity.

Results

We propose using immunohistochemistry image-derived information on the spatial distribution of cellular signal intensity (CSI) of protein expression within the cancer cell population to quantify both mean expression level and tumor heterogeneity of CSI levels. We view CSI levels as marks in a marked point process of cancer cells

SUBMITTER: Chervoneva I 

PROVIDER: S-EPMC8208754 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature