Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease.

ABSTRACT: Amyloid-β (Aβ) deposits, pathologic tau, and neurodegeneration are major pathological hallmarks of Alzheimer's disease (AD). The relationship between neuronal loss and Aβ deposits is one of the fundamental questions in the pathogenesis of AD. However, this relationship is controversial. One main reason for the conflicting results may be the confounding effects of pathologic tau, which often coexists with Aβ deposits in the brains of AD patients. To clarify the relationship between neuronal loss and Aβ deposits, mouse models of AD, which develop abundant Aβ deposits in the aged brain without pathologic tau, were used to examine the co-localization of NeuN-positive neurons, NF-H-positive axons, MBP-positive myelin sheaths, and Aβ deposits. Neuronal loss, as measured by decreased staining of

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8208784 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature