Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA-methylation modifying enzymes DNMT3A or TET2. We used DNA-methylation array and whole-genome sequencing data from four cohorts together comprising 5522 persons to study the association between CHIP, epigenetic clocks, and health outcomes. CHIP was strongly associated with epigenetic age acceleration, defined as the residual after regressing epigenetic clock age on chronological age, in several clocks, ranging from 1.31 years (GrimAge, p < 8.6 × 10^-7 ) to 3.08 years (EEAA, p < 3.7 × 10^-18 ). Mutations in most CHIP genes except DNA-damage response genes were associated with increases in several measures of age accel

SUBMITTER: Nachun D 

PROVIDER: S-EPMC8208788 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature