Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.

ABSTRACT: Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD) and aging individuals. It has been established that vascular calcification is a gene-regulated biological process resembling osteogenesis involving osteogenic differentiation. However, there is no efficient treatment available for vascular calcification so far. The natural polyamine spermidine has been demonstrated to increase life span and protect against cardiovascular disease. It is unclear whether spermidine supplementation inhibits vascular calcification in CKD. Alizarin red staining and quantification of calcium content showed that spermidine treatment markedly reduced mineral deposition in both rat and human vascular smooth muscle cells (VSMCs) under osteogenic conditions. Additiona

SUBMITTER: Liu X 

PROVIDER: S-EPMC8208796 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature