Network Pharmacology-Based Approach to Investigate the Molecular Targets of Rhubarb for Treating Cancer.

ABSTRACT:

Background

As a traditional Chinese medicine, rhubarb (also named Dahuang) is used to treat various diseases.

Objective

To explore the possible antitumor mechanism of rhubarb by using network pharmacology and molecular docking in this study.

Methods

Bioactive ingredients and related targets of rhubarb were obtained from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. And the gene names corresponding to the proteins were found in the UniProt database. Then, the tumor-related targets were screened out from GeneCards and OMIM databases. Key antitumor targets of rhubarb were acquired by overlapping the above targets via the Venn diagram. The antitumor targets network of rhubarb active components was constructed by using Cytoscape 3.6.0 software. Th

SUBMITTER: Jiang L 

PROVIDER: S-EPMC8208856 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature