Purinergic smooth muscle contractions in the human prostate: estimation of relevance and characterization of different agonists.

ABSTRACT: Non-adrenergic prostate smooth muscle contractions may account for the limited effectiveness of α₁-adrenoceptor antagonists, which are the first-line option for medical treatment of voiding symptoms suggestive of benign prostatic hyperplasia. In non-human prostates, purinergic agonists induce contractions reaching similar magnitudes as α₁-adrenergic contractions. However, evidence for the human prostate is highly limited, and pointed to much weaker purinergic contractions. Here, we examined contractions of different purinergic agonists in human prostate tissues. Tissues were obtained from radical prostatectomy. Contractions were studied in an organ bath, and expression of purinergic receptors was studied by RT-PCR. Electric field stimulation (EFS)-induced contractions

SUBMITTER: Spek A 

PROVIDER: S-EPMC8208936 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature