EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers.

ABSTRACT: Triple-negative breast cancer (TNBC) is characterized by low expression of human epidermal growth factor receptor-2 (HER2), estrogen receptor (ER), and progesterone receptor (PR), which is the most aggressive subtype with poor outcome among breast cancers. The underlying mechanisms of TNBC remain unclear and there is a lack of biomarkers. In this study we conducted an in silico assay and found that FOXC1 was highly expressed in ER^-/PR^-/HER2^- breast cancers, which was confirmed by qRT-PCR, immunohistochemistry, and Western blot analysis. FOXC1 was more highly expressed in TNBCs than the other breast cancers. Kaplan-Meier plotter revealed that expression of FOXC1 was associated with overall survival (OS) of patients with breast cancers. Expression of FOXC1 wa

SUBMITTER: Zheng XJ 

PROVIDER: S-EPMC8209002 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature