Oral pre-treatment with thiocyanate (SCN^-) protects against myocardial ischaemia-reperfusion injury in rats.

ABSTRACT: Despite improvements in revascularization after a myocardial infarction, coronary disease remains a major contributor to global mortality. Neutrophil infiltration and activation contributes to tissue damage, via the release of myeloperoxidase (MPO) and formation of the damaging oxidant hypochlorous acid. We hypothesized that elevation of thiocyanate ions (SCN^-), a competitive MPO substrate, would modulate tissue damage. Oral dosing of rats with SCN^-, before acute ischemia-reperfusion injury (30 min occlusion, 24 h or 4 week recovery), significantly reduced the infarct size as a percentage of the total reperfused area (54% versus 74%), and increased the salvageable area (46% versus 26%) as determined by MRI imaging. No difference was observed in fractional shortening,

SUBMITTER: Hall L 

PROVIDER: S-EPMC8209016 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature