Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.

ABSTRACT: SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin protomer as a modular subunit to drive oligomerization of antibody fragments and transform antibodies targeting SARS-CoV-2 into exceptionally potent neutralizers. Using this platform, half-maximal inhibitory concentration (IC₅₀) values as low as 9 × 10^-14 M are achieved as a result of up to 10,000-fold potency enhancements compared to corresponding IgGs. Combination of three different antibody specificities and the fragment crystallizable (Fc) domain on a single multivalent molecule conferred the ability to overcome viral sequence variability together with outstanding potency a

SUBMITTER: Rujas E 

PROVIDER: S-EPMC8209050 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature