Accelerated subcutaneous abdominal stem cell adipogenesis predicts insulin sensitivity in normal-weight women with polycystic ovary syndrome.

ABSTRACT:

Objective

To examine whether subcutaneous (SC) abdominal adipose stem cell differentiation into adipocytes in vitro predicts insulin sensitivity (Si) in vivo in normal-weight women with polycystic ovary syndrome (PCOS) and controls.

Design

Prospective cohort study.

Setting

Academic medical center.

Patient(s)

Eight normal-weight women with PCOS and 8 age- and body mass index-matched controls.

Intervention(s)

Women underwent circulating hormone/metabolic determinations, intravenous glucose tolerance testing, total-body dual-energy x-ray absorptiometry, and SC abdominal fat biopsy.

Main outcome measure(s)

PPARγ and CEBPa gene expression and lipid content of adipocytes matured in vitro were compared between women with PCOS and control women, and corre

SUBMITTER: Dumesic DA 

PROVIDER: S-EPMC8209112 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature