Imaging tau burden in dementia with Lewy bodies using [¹⁸F]-AV1451 positron emission tomography.

ABSTRACT: Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia with Lewy bodies (DLB). Here, we evaluated the in vivo distribution of tau burden and its influence on the clinical phenotype of DLB. Tau deposition was quantified using [¹⁸F]-AV1451 positron emission tomography in people with DLB (n = 10), AD (n = 27), and healthy controls (n = 14). A subset of patients with Lewy body diseases (n = 4) also underwent [¹¹C]-PK11195 positron emission tomography to estimate microglial activation. [¹⁸F]-AV1451 BP_ND was lower in DLB than AD across widespread regions. The medial temporal lobe [¹⁸F]-AV1451 BP_ND distinguished people with DLB from AD (AUC = 0.87), and negatively correlated with Addenbro

SUBMITTER: Mak E 

PROVIDER: S-EPMC8209140 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature