Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia.

ABSTRACT: Sepsis is life-threatening organ dysfunction due to dysregulated systemic inflammatory and immune response to infection, often leading to cognitive impairments. Growing evidence shows that artemisinin, an antimalarial drug, possesses potent anti-inflammatory and immunoregulatory activities. In this study we investigated whether artemisinin exerted protective effect against neurocognitive deficits associated with sepsis and explored the underlying mechanisms. Mice were injected with LPS (750 μg · kg^-1 · d^-1, ip, for 7 days) to establish an animal model of sepsis. Artemisinin (30 mg · kg^-1 · d^-1, ip) was administered starting 4 days prior LPS injection and lasting to the end of LPS injection. We showed that artemisinin administration significantly

SUBMITTER: Lin SP 

PROVIDER: S-EPMC8209200 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature