Protein residue network analysis reveals fundamental properties of the human coagulation factor VIII.

ABSTRACT: Hemophilia A is an X-linked inherited blood coagulation disorder caused by the production and circulation of defective coagulation factor VIII protein. People living with this condition receive either prophylaxis or on-demand treatment, and approximately 30% of patients develop inhibitor antibodies, a serious complication that limits treatment options. Although previous studies performed targeted mutations to identify important residues of FVIII, a detailed understanding of the role of each amino acid and their neighboring residues is still lacking. Here, we addressed this issue by creating a residue interaction network (RIN) where the nodes are the FVIII residues, and two nodes are connected if their corresponding residues are in close proximity in the FVIII protein structure. We studied

SUBMITTER: Lopes TJS 

PROVIDER: S-EPMC8209229 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature