Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma.

ABSTRACT: Colorectal carcinoma (CRC) is one of the most common cancers, and is associated with a poor clinical outcome. The key genes and potential prognostic markers in colorectal carcinoma remain to be identified and explored for clinical application. DNA expression/methylation profiles were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed/methylated genes (DEGs and DEMs). A total of 255 genes and 372 genes were identified as being up-regulated and down-regulated, respectively, in GSE113513, GSE81558, and GSE89076. There were a total of 3350 hypermethylated genes and 443 hypomethylated genes identified in GSE48684. Twenty genes were found to be hypermethylated as well as down-regulated, and a functional enrichment analysis revealed that these genes we

SUBMITTER: Ye Z 

PROVIDER: S-EPMC8209361 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature