Optical Control of CD8⁺ T Cell Metabolism and Effector Functions.

ABSTRACT: Although cancer immunotherapy is effective against hematological malignancies, it is less effective against solid tumors due in part to significant metabolic challenges present in the tumor microenvironment (TME), where infiltrated CD8⁺ T cells face fierce competition with cancer cells for limited nutrients. Strong metabolic suppression in the TME is often associated with impaired T cell recruitment to the tumor site and hyporesponsive effector function via T cell exhaustion. Increasing evidence suggests that mitochondria play a key role in CD8⁺ T cell activation, effector function, and persistence in tumors. In this study, we showed that there was an increase in overall mitochondrial function, including mitochondrial mass and membrane potential, during both mo

SUBMITTER: Amitrano AM 

PROVIDER: S-EPMC8209468 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature