Identification of a Competing Endogenous RNA Network Related to Immune Signature in Lung Adenocarcinoma.

ABSTRACT:

Background

The establishment of immunotherapy has led to a new era in oncotherapy. But the signature of immune-related genes (IRGs) in LUAD remains to be elucidated. Here we use integrated analysis to identify IRGs roles in immune signature and detect their relationship with competing endogenous RNA (ceRNA) networks in LUAD progression.

Methods

By analyzing the RNA-seq data from different platforms, we recognized the differentially expressed genes (DEGs) of each platform and screened out the top 20 hub IRGs related to immune responses. Then, we applied the CIBERSORT algorithm to explore the landscape of tumor-infiltrating immune cells (TILs) in LUAD and their connection with hub genes. Next, we predicted and validated the upstream miRNAs and lncRNAs according to their expres

SUBMITTER: Zhu T 

PROVIDER: S-EPMC8209499 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature