Exploration of the Role of m⁶ A RNA Methylation Regulators in Malignant Progression and Clinical Prognosis of Ovarian Cancer.

ABSTRACT: Ovarian cancer is the most deadly gynecologic malignancy worldwide and it is warranted to dissect the critical gene regulatory network in ovarian cancer. N6-methyladenosine (m⁶A) RNA methylation, as the most prevalent RNA modification, is orchestrated by the m⁶A RNA methylation regulators and has been implicated in malignant progression of various cancers. In this study, we investigated the genetic landscape and expression profile of the m⁶A RNA methylation regulators in ovarian cancer and found that several m⁶A RNA methylation regulators were frequently amplified and up-regulated in ovarian cancer. Utilizing consensus cluster analysis, we stratified ovarian cancer samples into four clusters with distinct m⁶A methylation patterns and p

SUBMITTER: Wei Q 

PROVIDER: S-EPMC8209520 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature