Association of Demographic Factors and Infantile Hemangioma Characteristics With Risk of PHACE Syndrome.

ABSTRACT:

Importance

A 2010 prospective study of 108 infants estimated the incidence of PHACE (posterior fossa malformations, hemangioma, arterial anomalies, cardiac defects, eye anomalies) syndrome to be 31% in children with facial infantile hemangiomas (IHs) of at least 22 cm2. There is little evidence regarding the associations among IH characteristics, demographic characteristics, and risk of PHACE syndrome.

Objectives

To evaluate demographic characteristics and comorbidities in a large cohort of patients at risk for PHACE syndrome and assess the clinical features of large head and neck IH that may be associated with a greater risk of a diagnosis of PHACE syndrome.

Design, setting, and participants

This multicenter, retrospective cohort study assessed all patients with a fa

SUBMITTER: Cotton CH 

PROVIDER: S-EPMC8209569 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature