Accelerator-based BNCT for patients with recurrent glioblastoma: a multicenter phase II study.

ABSTRACT:

Background

Boron neutron capture therapy (BNCT) utilizes tumor-selective particle radiation. This study aimed to assess the safety and efficacy of accelerator-based BNCT (AB-BNCT) using a cyclotron-based neutron generator (BNCT 30) and ¹⁰B-boronophenylalanine (SPM-011) in patients with recurrent malignant glioma (MG) (primarily glioblastoma [GB]).

Methods

This multi-institutional, open-label, phase II clinical trial involved 27 recurrent MG cases, including 24 GB cases, who were enrolled from February 2016 to June 2018. The study was conducted using the abovementioned AB-BNCT system, with 500 mg/kg SPM-011 (study code: JG002). The patients were bevacizumab-naïve and had recurrent MG after standard treatment. The primary endpoint was the 1-year survival rate, and t

SUBMITTER: Kawabata S 

PROVIDER: S-EPMC8209606 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature