Tumor necrosis factor-α gene promoter -308 and -238 polymorphisms and its serum level in psoriasis.

ABSTRACT:

Background

Psoriasis is a chronic, immune-mediated, inflammatory skin disease affecting genetically predisposed individuals and requiring long-term treatment. The etiology of psoriasis is not fully understood. This article aimed to determine association between genetic polymorphisms in tumor necrosis factor-α (TNF -α) promoter -308 (rs1800629) and -238 (rs 361,525) and its serum level in psoriasis patients.

Methods

The study was conducted on 70 patients with psoriasis and 70 age and sex-matched, healthy individuals. All patients were subjected to history taking and complete medical examination. The polymorphisms of TNF -α promoter gene -308 (rs1800629) and -238 (rs 361,525) were detected by real time PCR and Serum levels of TNF -α were measured by ELISA technique.

SUBMITTER: Hagag MM 

PROVIDER: S-EPMC8209664 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature