Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors.

ABSTRACT: The extensive length, compaction, and interwound nature of DNA, together with its controlled and restricted movement in eukaryotic cells, create a number of topological issues that profoundly affect all of the functions of the genetic material. Topoisomerases are essential enzymes that modulate the topological structure of the double helix, including the regulation of DNA under- and overwinding and the removal of tangles and knots from the genome. Type II topoisomerases alter DNA topology by generating a transient double-stranded break in one DNA segment and allowing another segment to pass through the DNA gate. These enzymes are involved in a number of critical nuclear processes in eukaryotic cells, such as DNA replication, transcription, and recombination, and are required for proper chr

SUBMITTER: Vann KR 

PROVIDER: S-EPMC8209676 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature