bla_OXA-48-like genome architecture among carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the Netherlands.

ABSTRACT: Carbapenem-hydrolysing enzymes belonging to the OXA-48-like group are encoded by bla_OXA-48-like alleles and are abundant among Enterobacterales in the Netherlands. Therefore, the objective here was to investigate the characteristics, gene content and diversity of the bla_OXA-48-like carrying plasmids and chromosomes of Escherichia coli and Klebsiella pneumoniae collected in the Dutch national surveillance from 2014 to 2019 in comparison with genome sequences from 29 countries. A combination of short-read genome sequencing with long-read sequencing enabled the reconstruction of 47 and 132 complete bla_OXA-48-like plasmids for E. coli and K. pneumoniae, respectively. Seven distinct plasmid groups designate

SUBMITTER: Hendrickx APA 

PROVIDER: S-EPMC8209719 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature