Determination and clinical significance of bone pseudoprogression in hormone receptor-positive metastatic breast cancer.

ABSTRACT:

Background

^99mTechnetium labeled methylene diphosphonate bone scans (BSs) are commonly used to monitor disease progression in bone for patients with metastatic breast cancer (MBC). However, new BS lesions may represent osteoblastic bone healing, which we now define as bone pseudoprogression. In this study, we aimed to assess the clinical significance and determination methods of bone pseudoprogression.

Methods

This retrospective analysis was conducted among 48 patients with hormone receptor-positive MBC treated with first-line endocrine therapy. Four months after initiating therapy, all the participants did not show extraosseous disease progression. Participants were divided into two groups according to the presence of new BS lesions. All the patients continued on

SUBMITTER: Lin M 

PROVIDER: S-EPMC8209838 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature