Ontology highlight
ABSTRACT:
SUBMITTER: Lai KY
PROVIDER: S-EPMC8209957 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Lai Kuan-Yu KY Galan Sébastien R G SRG Zeng Yibo Y Zhou Tianhui Hina TH He Chang C Raj Ritu R Riedl Jitka J Liu Shi S Chooi K Phin KP Garg Neha N Zeng Min M Jones Lyn H LH Hutchings Graham J GJ Mohammed Shabaz S Nair Satish K SK Chen Jie J Davis Benjamin G BG van der Donk Wilfred A WA
Cell 20210430 10
Enzyme-mediated damage repair or mitigation, while common for nucleic acids, is rare for proteins. Examples of protein damage are elimination of phosphorylated Ser/Thr to dehydroalanine/dehydrobutyrine (Dha/Dhb) in pathogenesis and aging. Bacterial LanC enzymes use Dha/Dhb to form carbon-sulfur linkages in antimicrobial peptides, but the functions of eukaryotic LanC-like (LanCL) counterparts are unknown. We show that LanCLs catalyze the addition of glutathione to Dha/Dhb in proteins, driving irr ...[more]