The emergence of azithromycin-resistant Salmonella Typhi in Nepal.

ABSTRACT:

Background

Typhoid fever remains a significant cause of morbidity and mortality in Asia and Africa. The emergence of azithromycin resistance in South Asia is concerning, as azithromycin is one of the last effective oral drugs for treating typhoid.

Objectives

To describe the molecular mechanism and phylogenetics of azithromycin-resistant (Azith^R) Salmonella Typhi isolates from Patan Hospital, Kathmandu, Nepal.

Methods

Whole-genome sequences of three Azith^R  S. Typhi isolates (MIC >256 mg/L) were analysed and compared with a global collection to investigate the azithromycin resistance mechanism and phylogenetic structure. Clinical information is reported for one of the three patients infected with Azith^R  S. Typhi.

SUBMITTER: Duy PT 

PROVIDER: S-EPMC8210228 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature