Dissemination mechanisms of NDM genes in hospitalized patients.

ABSTRACT:

Background

NDM-producing Enterobacteriaceae are a major clinical concern worldwide. We characterized NDM-positive pathogens isolated from patients and assessed the dissemination patterns of the bla _NDM genes in a hospital setting.

Methods

Eleven NDM-positive Enterobacteriaceae (three Enterobacter hormaechei, six Klebsiella pneumoniae and two Escherichia coli) were isolated from nine patients over a 1 year period. Antimicrobial susceptibility was assessed by MICs. A combination of short- and long-read WGS was used for genome analysis. Clinical treatment history of patients was linked with genetic features of individual isolates to investigate the dissemination patterns of the bla _NDM genes and NDM-positive strains.

R

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC8210240 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature