Transcriptomic coordination at hepatic steatosis indicates robust immune cell engagement prior to inflammation.

ABSTRACT:

Background

Deregulation in lipid metabolism leads to the onset of hepatic steatosis while at subsequent stages of disease development, the induction of inflammation, marks the transition of steatosis to non-alcoholic steatohepatitis. While differential gene expression unveils individual genes that are deregulated at different stages of disease development, how the whole transcriptome is deregulated in steatosis remains unclear.

Methods

Using outbred deer mice fed with high fat as a model, we assessed the correlation of each transcript with every other transcript in the transcriptome. The onset of steatosis in the liver was also evaluated histologically.

Results

Our results indicate that transcriptional reprogramming directing immune cell engagement proceeds robustly,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8210377 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature