Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank.

ABSTRACT:

Background

Serum urate is the most abundant small molecule with antioxidant properties found in blood and the epithelial lining fluid of the respiratory system. Moderately raised serum urate is associated with lower rates of lung cancer and COPD in smokers but whether these relationships reflect antioxidant properties or residual confounding is unknown.

Methods

We investigated the observational and potentially causal associations of serum urate with lung cancer incidence and FEV₁ using one-sample Mendelian randomization (MR) and the UK Biobank resource. Incident lung cancer events were identified from national cancer registries as FEV₁ was measured at baseline. Observational and genetically instrumented incidence rate ratios (IRRs) and risk differences

SUBMITTER: Horsfall LJ 

PROVIDER: S-EPMC8210393 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature