New Micropeptins with Anti-Neuroinflammatory Activity Isolated from a Cyanobacterial Bloom.

ABSTRACT: Metabolite mining of environmentally collected aquatic and marine microbiomes offers a platform for the discovery of new therapeutic lead molecules. Combining a prefractionated chromatography library with liquid chromatography tandem mass spectrometry (LC-MS/MS)-based molecular networking and biological assays, we isolated and characterized two new micropeptins (1 and 2) along with the previously characterized micropeptin 996. These metabolites showed potency in anti-neuroinflammatory assays using BV-2 mouse microglial cells, showing a 50% reduction in inflammation in a range from 1 to 10 μM. These results show promise for cyanobacterial peptides in the therapeutic realm apart from their impact on environmental health and provide another example of the utility of large prefra

SUBMITTER: Kirk RD 

PROVIDER: S-EPMC8210450 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature