Cardiac Amyloidosis: Multimodal Imaging of Disease Activity and Response to Treatment.

ABSTRACT: Cardiac amyloidosis (CA) is a disease characterized by the deposition of misfolded protein deposits in the myocardial interstitium. Although advanced CA confers significant morbidity and mortality, the magnitude of deposition and ensuing clinical manifestations vary greatly. Thus, an improved understanding of disease pathogenesis at both cellular and functional levels would afford critical insights that may improve outcomes. This review will summarize contemporary therapies for the 2 major types of CA, transthyretin and light chain amyloidosis, and outline the capacity of imaging modalities to both diagnose CA, inform prognosis, and follow response to available therapies. We explore the current landscape of echocardiography, cardiac magnetic resonance, and bone scintigraphy in the assessme

SUBMITTER: Patel RK 

PROVIDER: S-EPMC8210461 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature