Data mining analysis of the prognostic impact of N⁶-methyladenosine regulators in patients with endometrial adenocarcinoma.

ABSTRACT: We reanalyzed the expression of 16 acknowledged N⁶-methyladenosine (m⁶A) RNA regulators in 406 endometrial adenocarcinoma patients and 19 controls using The Cancer Genome Atlas (TCGA) dataset, and further verified our results using Gene Expression Omnibus (GEO) dataset and real-time quantitative polymerase chain reaction. Thirteen m⁶A RNA methylation regulators were differentially expressed between patients with endometrial adenocarcinoma and controls. FTO, RBM15, and YTHDF1, were identified as independent prognostic markers and closely associated with International Federation of Gynecology and Obstetrics grade in endometrial cancer patients. GEO dataset also verified the differential expression of FTO and RBM15 between patients with endometrial adenocarcin

SUBMITTER: Zhai J 

PROVIDER: S-EPMC8210566 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature