Metastatic and sentinel lymph node mapping using intravenously delivered Panitumumab-IRDye800CW.

ABSTRACT: Rationale: Sentinel lymph node biopsy (SLNB) is a well-established minimally invasive staging procedure that maps the spread of tumour metastases from their primary site to the regional lymphatics. Currently, the procedure requires the local peri-tumoural injection of radiolabelled and/or optical agents, and is therefore operator dependent, disruptive to surgical workflow and restricted largely to a small subset of malignancies that can be readily accessed externally for local tracer injection. The present study set out to determine whether intravenous (IV) infusion of a tumor-targeted tracer could identify sentinel and metastatic lymph nodes (LNs) in order to overcome these limitations. Methods: We examined 27 patients with oral squamous cell carcinoma (OSCC), 18 of whom wer

SUBMITTER: Krishnan G 

PROVIDER: S-EPMC8210603 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature