Adiposity Change Over the Life Course and Mammographic Breast Density in Postmenopausal Women.

ABSTRACT: Mammographic breast density is a strong risk factor for breast cancer. We comprehensively investigated the associations of body mass index (BMI) change from ages 10, 18, and 30 to age at mammogram with mammographic breast density in postmenopausal women. We used multivariable linear regression models, adjusted for confounders, to investigate the associations of BMI change with volumetric percent density, dense volume, and nondense volume, assessed using Volpara in 367 women. At the time of mammogram, the mean age was 57.9 years. Compared with women who had a BMI gain of 0.1-5 kg/m² from age 10, women who had a BMI gain of 5.1-10 kg/m² had a 24.4% decrease [95% confidence interval (CI), 6.0%-39.2%] in volumetric percent density; women who had a BMI gain of 10.1-15 kg/m

SUBMITTER: Han Y 

PROVIDER: S-EPMC8210631 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature