Estrogenicity of chemical mixtures revealed by a panel of bioassays.

ABSTRACT: Estrogenic compounds are widely released to surface waters and may cause adverse effects to sensitive aquatic species. Three hormones, estrone, 17β-estradiol and 17α-ethinylestradiol, are of particular concern as they are bioactive at very low concentrations. Current analytical methods are not all sensitive enough for monitoring these substances in water and do not cover mixture effects. Bioassays could complement chemical analysis since they detect the overall effect of complex mixtures. Here, four chemical mixtures and two hormone mixtures were prepared and tested as reference materials together with two environmental water samples by eight laboratories employing nine in vitro and in vivo bioassays covering different steps involved in the estrogenic response. The reference materials incl

SUBMITTER: Gomez L 

PROVIDER: S-EPMC8210648 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature