Wnt signaling related transcripts and their relationship to energy metabolism in C2C12 myoblasts under temperature stress.

ABSTRACT: Temperature stress is one of the main environmental stressors affecting the welfare, health and productivity of livestock. Temperature changes can modify cell membrane components, disrupting the crosstalk between the cell and its surroundings by affecting signaling pathways including Wnt signaling pathway, which subsequently disrupts cell energy metabolism. The present study aims to understand the effect of temperature stress on the expression of genes involved in Wnt signaling pathways, and their interaction with energy metabolism in C2C12 myoblasts cells. The C2C12 cells were exposed to cold stress (35 °C), mild heat stress (39 °C) and severe heat stress (41 °C), whereas 37 °C was used as control temperature. Transcript levels of important genes involved in Wnt signaling including Axi

SUBMITTER: Risha MA 

PROVIDER: S-EPMC8210811 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature