Identification of copy number variations and translocations in cancer cells from Hi-C data.

ABSTRACT:

Motivation

Eukaryotic chromosomes adapt a complex and highly dynamic three-dimensional (3D) structure, which profoundly affects different cellular functions and outcomes including changes in epigenetic landscape and in gene expression. Making the scenario even more complex, cancer cells harbor chromosomal abnormalities [e.g. copy number variations (CNVs) and translocations] altering their genomes both at the sequence level and at the level of 3D organization. High-throughput chromosome conformation capture techniques (e.g. Hi-C), which are originally developed for decoding the 3D structure of the chromatin, provide a great opportunity to simultaneously identify the locations of genomic rearrangements and to investigate the 3D genome organization in cancer cells. Even though Hi-C da

SUBMITTER: Chakraborty A 

PROVIDER: S-EPMC8210825 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature