Expression of corticosteroid-regulated genes by PBMCs in children with asthma.

ABSTRACT:

Background

Variability in response to inhaled corticosteroids (ICSs) can result in less than optimal asthma control. Development of biomarkers assessing the therapeutic efficacy of corticosteroids is important.

Objective

We sought to examine whether in vitro PBMC responses to corticosteroids relate to the clinical ICS response.

Methods

PBMCs were collected from 125 children with asthma (6-17 years) at enrollment (visit 0 [V0]) and after 1 year of bimonthly guidelines-based management visits (visit 6 [V6]). Difficult-to-control and easy-to-control asthma were defined as requiring daily therapy with 500 μg or more of fluticasone propionate (FLU) with or without a long-acting β-agonist versus 100 μg or less of FLU in at least 4 visits. mRNA levels of glucocorticoid recep

SUBMITTER: Goleva E 

PROVIDER: S-EPMC8210855 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature