Integrating gut microbiome and host immune markers to understand the pathogenesis of Clostridioides difficile infection.

ABSTRACT: Clostridioides difficile (C. difficile) infection is the most common cause of healthcare-associated infection and an important cause of morbidity and mortality among hospitalized patients. A comprehensive understanding of C. difficile infection (CDI) pathogenesis is crucial for disease diagnosis, treatment, and prevention. Here, we characterized gut microbial compositions and a broad panel of innate and adaptive immunological markers in 243 well-characterized human subjects (including 187 subjects with both microbiota and immune marker data), who were divided into four phenotype groups: CDI, Asymptomatic Carriage, Non-CDI Diarrhea, and Control. We found that the interactions between gut microbiota and host immune markers are very sensitive to the status o

SUBMITTER: Ke S 

PROVIDER: S-EPMC8210874 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature