Identifying the key microRNAs implicated in atrial fibrillation.

ABSTRACT:

Objective

This study investigated the potential microRNAs (miRNAs) having a diagnostic value in atrial fibrillation (AF).

Methods

The miRNA and mRNA expression profiles of atrial tissue from healthy individuals and patients with AF were downloaded from the Gene Expression Omnibus database. Differentially expressed miRNAs/mRNAs (DEMis/DEMs) were identified in patients with AF. Furthermore, an interaction network between DEMis and DMEs was constructed. The biological processes, molecular functions, and signaling pathways of DEMs were enriched. Then, the diagnostic values of candidate DECs among healthy individuals and patients with AF were preliminarily evaluated in the GSE101586, GSEE101684, and GSE112214 datasets.

Results

Twenty DEMis were identified in patients with

SUBMITTER: Cao Y 

PROVIDER: S-EPMC8210928 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature