Identification of candidate gene variants of monogenic diabetes using targeted panel sequencing in early onset diabetes patients.

ABSTRACT:

Introduction

Monogenic diabetes is attributed to genetic variations in a single gene. Maturity-onset diabetes of the young (MODY) is the most common phenotype associated with monogenic diabetes, but is frequently misdiagnosed as either type 1 or type 2 diabetes. Increasing our basic understanding of genetic variations in MODY may help to improve the accuracy of providing the correct diagnosis and personalize subsequent treatment regimens in different racial populations. For this reason, this study was designed to identify nucleotide variants in early onset diabetes patients with clinically suspected MODY in a Korean population.

Research design and methods

Among 2908 Korean patients diagnosed with diabetes, we selected 40 patients who were diagnosed before 30 years old and we

SUBMITTER: Lee DH 

PROVIDER: S-EPMC8211067 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature