Effect of cellular rearrangement time delays on the rheology of vertex models for confluent tissues.

ABSTRACT: Large-scale tissue deformation during biological processes such as morphogenesis requires cellular rearrangements. The simplest rearrangement in confluent cellular monolayers involves neighbor exchanges among four cells, called a T1 transition, in analogy to foams. But unlike foams, cells must execute a sequence of molecular processes, such as endocytosis of adhesion molecules, to complete a T1 transition. Such processes could take a long time compared to other timescales in the tissue. In this work, we incorporate this idea by augmenting vertex models to require a fixed, finite time for T1 transitions, which we call the "T1 delay time". We study how variations in T1 delay time affect tissue mechanics, by quantifying the relaxation time of tissues in the presence of T1 delays and comparing

SUBMITTER: Erdemci-Tandogan G 

PROVIDER: S-EPMC8211246 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature