Apolipoprotein L1 and mechanisms of kidney disease susceptibility.

ABSTRACT:

Purpose of review

Allelic variants in the gene for apolipoprotein L1 (APOL1), found only in individuals of African ancestry, explain a majority of the excess risk of kidney disease in African Americans. However, a clear understanding how the disease-associated APOL1 variants cause kidney injury and the identity of environmental stressors that trigger the injury process have not been determined.

Recent findings

Basic mechanistic studies of APOL1 biochemistry and cell biology, bolstered by new antibody reagents and inducible pluripotent stem cell-derived cell systems, have focused on the cytotoxic effect of the risk variants when APOL1 gene expression is induced. Since the APOL1 variants evolved to alter a key protein-protein interaction with the trypanosome serum resistance-a

SUBMITTER: Bruggeman LA 

PROVIDER: S-EPMC8211384 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature